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In rodent models, BPC-157 demonstrated a wide therapeutic index with no observed hepatotoxicity, nephrotoxicity, or neurotoxicity across multiple dosing regimens. Sikiric et al., Regenerative Pharmacology Reported Side Effects (Rare) While side effects are rare, some users report: Peptides like BPC-157 generally exhibit low immunogenicity and low systemic toxicity, though user-specific variables such as injection technique or gut sensitivity may influence short-term side effects. [Clinical Peptide Society Review, 2021] Is BPC-157 Safe for Long-Term Use

Since a typical pen is used up within a month, you shouldnt have to worry about refrigerating it again